Some Coagulation Parameters Among Sudanese Children with Schistosomiasis in River Nile State

Abstract

This is descriptive analytical study carried out in the River Nile state , in the period from (May 2012 to july 2012) to evaluate some coagulation parameter among Sudanese children infected with schistosomiasis. seventy five children were selected ,59(78%) ofthem were male and 16(22%)female and twenty five healthy individuals were selected as control group . 4.5 ml of venous blood were drown from each child , placed in tri sodium citrate container , then centrifuge to get platelets poor plasma (ppp) and to assess PT , APTT, fibrinogen and D.dimer ,The data were analyzed by using statistical package for social sciences (SPSS) versionl 11.5 , and express as means . The results show that the means of PT(prothrombin time),16sec,APPT(activate partial thromboplastin time)34sec,fibrinogen level was 342mg/dl and D-dimer level was 231ng/l respectively . The mean of PT,APTT, Fibrinogen and D.dimer in control group were found to be 13sec, 32sec, 286 mg/dl, 192ng/l respectively . The results showed no significant differences between the means of PT of patients and controls , but demonstrated a significant differences between the mean of patients and controls (APTT) , fibrinogen level and D.dimer of patient and control (p.value <0.05). The result obtained indicated that measurement of PT was unnecessary when evaluating schistosomiasis patients whom there was clinical evidence of hemostatic abnormality . The results of this study raised the possibility of APTT , fibrinogen level and D.dimer to be used in identifying risk group of schistosomiasis patients who were likely to develop thrombotic events.