Determination of the Prevelance of HbS in El-Tonjure Tribe Population Who Live in Khartoum State

Abstract

This study is an analytical descriptive study a cross sectional study to determine sickle cell trait frequency in families belong to El- Tonjure Sudanese tribe, which is considered to be one of Western Sudan tribes . This study was done in the period from October 2008 to April 2009. Informed consent was taken from 100 individuals from 14 different families belonging to El-Tonjure tribe, and 2.5 ml of venous blood in ethylene-diamine-tetra-acetic acid (EDTA) containers was collected from each, and investigated for presence of Hb S, complete blood count (CBC), sickling test and Hb electrophoresis . Fully automated heamatological analyzer (Sysmex Kx 21N), Electrophoresis tank and power pack were used. The data were analyzed by computer using the statistical program Statistical Package for Social Sciences (SPSS). Participants in this study included 46 male and 54 females, sickling test showed 18% were positive and 82% were negative o f the study population . Hb electrophoresis showed 17% sickle cell trait. 1% sickle cell disease and 82% normal Hb. The mean age of the sickle cell patients was 11 years, and sicle cell trait 39.18 years. The mean Hb concentration among the Hb SS patient was 6.20 mg/dl, and among Hb AS carriers was 12.74 ml/dl. And among Hb AA was 12.88ml/ dl. The total leukocyte count mean was 18.60*103 cell/cu.ml, and platelet counts mean was 450000/cu,ml in sickle cell disease while in sickle cell trait was 4.75*103 cell/cu nl and 236.4*103 cell/cu nl respectively . In conclusion sickle cell anaemia is not of high frequency in the Tonjure tribe. Results were compared with other Sudanese tribes’ results and we found that they are compatible with some results and not compatible with others.