Evaluation of Serum Zinc and Magnesium Level among Type II Diabetes Mellitus Patients - Khartoum State

Abstract

This analytical case control study conducted in Jabber Abu AI-iz Diabetic health center and Saad Rashwan Medical center during the period from June to February 2014, aimed to evaluate serum levels of zinc and magnesium among Sudanese patients with type II Diabetes mellitus. Sixty three samples were taken and compare with fourty five apparently healthy volunteer as a control group. Participants age ranged between 35-70 years old. Zn was assessed using standard biochemical technique , glucose and Mg were examined using spectrophotometric technique. Data was analyzed by SPSS version 15. The mean serum level of zinc (mg/L) in test and control group (0.457 ± 0.11) (0.496 ± 0.07) (P- value= 0.047), Mg (1.943 ± 0.28) (2.291 ± 0.27) (P value= 0.000) and glucose (181 ± 84.4) (86 ± 12.7) (P value= 0.000) respectively. The level of Mg, Zn and glucose were significantly difference in test group as compared to control group (P value ˂0.05). In diabetic group there was no correlation between zinc ,Magnesium and glucose with duration of disease (p > 0.05). There was weak negative correlation between glucose and Zinc (r = -0.229 ,P-value =0.017) and also glucose with Mg ( r = -0.309 ,p value =0.001). Age showed no correlation with zinc and glucose (P<0.001),but weak negative correlation with magnesium (r= -0.145 ,p-value =0.134). This study conclued that ,the levels of zinc and magnetism are differentially changed in the studied groups ,they decrease in diabetic patients with type II diabetes mellitus