Assessment of Serum Thyroid Hormones and Thyroid Stimulating Hormone Among Sudanese Smokers in Khartoum State

Abstract

This study was conducted in Khartoum State during the period from April to October 2013; its community based case control study. Objectives of the study: the main aim of the study is to assess the thyroid hormones among Sudanese smokers in Khartoum State . Materials and methods : Eighty plasma samples were collected from healthy heavy Sudanese smokers at different ages . In addition to 50 plasma samples from healthy non smokers at different ages for comparison, of thyroid stimulating hormone (TSH) , thyroxine (T4) and tri-iodothyronine (T3) . The level of thyroid hormones in the study was estimated by Omega pathozyme method using Enzyme immunoassay. Results : the study showed significant increase in thyroxine (T4) , tri-iodothyronine (T3) level in healthy heavy smokers when compared with the control group .( 146.8 ±39.0 versus 96.7 ± 25.4 ng /ml , 2.36 ± 0.76 versus 1.96 ± 0.59 nml/ml respectively ) , ( p ≤ 0.05 ) , with significant decrease in Thyroid stimulating hormone (TSH) ( 1.68 ± 1.11 versus 2.21 ± 0.99 μIU/ml respectively ), ( p ≤ 0.05 ) , The study recorded significant correlation between thyroid hormones and both age and the duration of smoking ( p > 0.05 ) . Conclusion : The study revealed significant increase in thyroxine (T4) , tri- iodothyronine (T3) with significant decrease in thyroid stimulating hormone (TSH) in healthy smokers.