Plasma Proteins in Allergic Asthma Patients

Abstract

A prospective study conducted during the period of February to October 2002 , to investigate serum protein (total protein, albumin, and globulin) of 45 allergic asthmatic patients, chosen from Khartoum North Teaching Hospital and 30 apparently health individuals as control.. -Serum proteins in asthmatic patients were separated into five bands (albumin, alpha1-globulin, alpha2-g1obulin, beta-globulin, and gamma- globulin). The serum levels of total protein was significantly raised (P<0.05) in the allergic asthmatic patients compared to the control.(7.0 + 0.6 versus 7.4 + 0.41 g/dl, p<0.05). Serum levels of albumin and globulin showed no significant difference in allergic asthmatic patient compared to the control (p>o.05) (4.4 + 0.39 versus 3.9 + 0.45 g/dl, p>0.05) for albumin and (2.4 + 0.4 versus 4.1 +: 0.5 g/dl p>0.05) for globulin. To study the effect of the duration of allergic asthma patients on Serum total protein, albumin, and globulin, the asthmatic patients (n=45) were divided into two subgroups, group (a) <10 years duration of disease (n=22) and subgroup (b) >10 years duration of disease (n=23). It was found that serum levels of total protein were significantly raised in group (a), compared to group (b). (7.0 + 0.49 versus 7.2 + 0.74 g/dl, p<0.05). Serum levels of albumin and globulin were showed no significant Increase with increase duration of the disease. (4.0 +0.48 versus 3.9 +0.43 g/dl, p>0.05) for albumin and (3.0 + 0.37 versus 3.2 + 0.48 g/dl, p>0.05) for globulin. This study concluded that, allergic asthma is one of the causes of raised serum level of total proteins, and it doesn't affect the levels of serum albumin and globulin.