Detection of Haemoglobin Patterns among Sickle Cell Haemoglobinopatheis of Patients Attending Military Hospital

Abstract

This descriptive case control study was conducted to determine the types, patterns and level by percent (%) of the haemoglobins among Sudanese patients with sickle cell haemoglobinopatheis through the period of March 2012 up to May 2012, using Capillay Electrophoresis technology. The total number of study group was one hundred, seventy patients group and thirty as control group. 51.4% of patients group were female while 48.6% were male. The study reveals the distribution rate of sicklling cell haemoglobinopatheis among all age groups. The study results shows that the frequency of AS patterns were 52.9%, AS/C patterns were 1.4%, S/BThalassemia patterns were 11.4%, SC patterns were 1.4%, SD patterns were 4.3% and SS patterns were 28.6%. However, all patients with sickle cell haemoglobinopatheis might have the abnormal form of haemoglobin (HbS) even in small amount. Hence, the amount of HbS (Mean) show 39.23% of AS pattern, 42.8% of ASC pattern, 47.5% of SC pattern, 11.64% of S/βThalassemia, 56.3% of SD pattern and 84.1% of SS pattern. The study also reveals that the mean of haemoglobin A pattern in patients group were statistically significant lower than means of control group (P value < 0.05).‫‪The study also explain the rate effect of HbF on the type‬‬ ‫‪of treatment, if the mean was 13.62 % and it is‬‬ ‫‪statistically significant higher than means of control group‬‬ ‫.)50.0 > ‪(P. value‬‬ ‫‪exception‬‬ ‫‪of‬‬ ‫‪(with‬‬ ‫‪differences‬‬ ‫‪haemoglobinopatheis‬‬ ‫‪significant‬‬ ‫‪non‬‬ ‫‪cell‬‬ ‫‪sickle‬‬ ‫‪In‬‬ ‫)‪S/βThalassemia‬‬ ‫‪haemoglobin A2 in comparison with control group (P. value‬‬ ‫‪> 0.05), while Hb F and Hb S show significant elevation‬‬ ‫‪respectively in comparison with control group (P. value‬‬ < 0.05) ‫