Evaluation of Some Coagulation Parameters in Obese Diabetic Patients in Khartoum State

Abstract

Obesity and diabetes mellitus were risk factors in the development of thrombosis .This risk is related to that of background population . in general , thrombosis in obese diabetic patients is associated with endothelial dysfunction , elevated inflammation markers and activated platelets and coagulation factor . This analytical case control study carried out in Khartoum State in the period of May 2013 to August 2013 , to evaluate haemostatic mechanism among Sudanese obese diabetic patients. .Fifty obese diabetic patient were selected , and other thirty were considred as control group . 4.5 ml of venous blood was withdrawn from each patient , placed in tri sodium citrate container , then centrifuged to get platelet poor plasma (PPP) in order to assess Prothrombin Time (PT ) , activated partial thromboplastin time ( APTT ) and fibrinogen level. . The results were analyzed by SPSS version 11.5 and expressed as mean the result obtained from obese diabetic patient show that the means of PT , APTT and fibrinogen in case were 13.19 Sec , 35.22 Sec and 2.79 g/l were respectively . The mean of PT , APTT and Fibrinogen in control group were 13.10 Sec , 33.41Sec and 2.00 g/l respectively . This result showed slight increase in the means of these parameters of patients compared with control group but insignificant difference between the mean of patient and control in Prothrombin time ( PT ) ( P. value > 0.05 ) , Activated partial thromboplastin time ( APTT ) ( P. value > 0.05 ) and Fibrinogen ( P. value > 0.05 ) . The result showed insignificant difference in PT and APTT in study group of age groups and duration groups ( P. value > 0.05 ) , significant difference in fibrinogen level in study group of age groups and duration groups ( P.value < 0.05 ) , insignificant difference in PT and Fibrinogen level in study group of BMI groups ( P.value > 0.05 ) and significant difference in APTT in study group of BMI groups ( P.value < 0.05 ) . The results show PT , APTT and fibrinogen level of study group in normal rang , the value of fibrinogen is affected by age and duration of disease and the value of APTT is effected by BMI . In conclusion The result obtain indicated that measurements of PT , APTT and fibrinogen level in obese diabetic patient were necessary to prevent complications that may lead to thrombosis.