Sero-detection of Rubella Virus and Cytomegalovirus Antibodies among Pregnant Women in Khartoum State

Abstract

The main aim of this study is to investigate infection of pregnant women by rubella and Cytomegalovirus ( CMV ) in Khartoum State, during the period from March to July , 2013 . Blood samples were aseptically, collected from ninety pregnant women (n=90) with all three trimesters of pregnancy attending different antinatel clinics (Omdurman Teaching Hospital , Khartoum North Teaching Hospital , and Alsaudi Hospital). Enzyme- Linked Immunosorbent Assay (ELISA) was used to detect rubella and CMV ( IgM and IgG ) antibodies in the sera of all tested women . The results obtained that IgM for rubella and CMV were 13.3% and 22.2% , respectively , while IgG for rubella and CMV were 74.4% and 77.8% , respectively . The highest frequency of rubella IgM ( 27% ) was detected among the age group 26-31 years , the lowest ( 5% ) was observed among the age group 38-43 years ; while the highest rubella IgG ( 80 % ) was detected among the age group 38-43 years , the lowest ( 67% ) was observed among the age group 20- 25 years. Moreover , while the highest frequency of CMV IgM ( 28 % ) was detected among the age group 20 - 25 years , the lowest ( 14 % ) was observed among the age group 26 - 31 years . For CMV IgG while the highest frequency ( 86 % ) was detected among the age group 26-31 years , the lowest ( 72% ) was observed among the age group 20-25 years . The highest frequencies of positive rubella and CMV IgM and IgG were observed among the first trimester of pregnancy . However , no significant difference (P > 0.05) was observed among the three trimesters and the different age groups of all pregnant women examined in this study .