Estimation of Some Coagulation Tests Among Sudanese Multigravida Pregnant Women in Saudi Maternity Hospital – Khartoum State

Abstract

This is a descriptive analytical study carried out in Khartoum state in the period of May 2012, to evaluate hemostatic mechanism among Sudanese multigravida pregnant women in third trimester. Fifty multigravida pregnant women in third trimester were selected, and twenty five healthy females non pregnant were selected as control group. Five and half ml of venous blood was drown from each patient and placed in tri sodium citrate container, then centrifuged to get platelets poor plasma (PPP) and that is to asses prothrombin time (PT), activated partial thromboplastin time (APTT), Fibrinogen level and D.dimer. The results were analyzed by SPSS version 11.5 and express as mean values the results obtained from cases that the means of PT (14.1sec), APTT (37.5 sec), Fibrinogen (571mg/dl) and D.dimer (1167ng/ml) respectively. The mean of PT, APTT, Fibrinogen and D.dimer in control group were (12.8sec), (31.3 sec), (205mg/dl) and (291ng/dl) respectively. The results showed significant increase between the mean of cases and controls in prothrombin time PT (P value <0.05), activated partial thromboplastin time APTT (P value <0.05), Fibrinogen (P value <0.05) and D.dimer (P value <0.05). The result show insignificant differences between age groups, month of the third trimesters and number of pregnancies. The results obtained indicated that measurement of prothrombin time (PT), Activated partial thromboplastin time (APTT), Fibrinogen and D.dimer were necessary when evaluating multigravida pregnant women, whom there was clinical evidence of hemostatic abnormality.