Estimation of Some Haemostatic Parameters in Patients With Liver Disease in Khartoum State

Abstract

This is a descriptive analytical study carried out in Khartoum state during the period of March 2012 to July 2012, to evaluate some haemostatic parameters among lives diseases patient .Fifty samples with diagnosed liver disease, were selected, and twenty five healthy individual were selected as control group The study population were liver disease patients that include two gall cholecytitis(4 %) ,six obstructive jaundice (12%) , eleven liver cirrhosis (22.0%) , eighteen HBV(36%) , eleven HCV (22%) , and two liver metastasis (4%). The gender distribution were females 33 (44.7 %), and males 42 (55.3%). The marital status among the study population was married46 (60.5%) and single 29 (39.5%). , 2.5 ml of venous blood withdrawn from each patient and control, placed in trisodium citrate container, then centrifuged to obtain platelets poor plasma (PPP)for measuring Prothrombin time (PT), activated thromboplastin time (APTT), thrombin time (TT) and fibrinogen level. .The compare mean of liver diseases each alone include that PT of cirrhosis ,jaundice ,HBV ,HCV, Gallcholecytitis, and liver metastasis are (20.0sec) The results were analyzed by SPSS version 11.5 and express as means; the results obtained showed that the means of PT (17.0sec), APTT (40.0sec), TT (19.0sec) and fibrinogen level (262.0mg/dl) respectively. The mean of PT, PTT, TT, and fibrinogen level of control group were (13.0sec), (31.0sec), (13.0sec), and (222.0mg/dl) respectively. The results showed highly significant differences between the mean values of patients in compare to controls in Prothrombin time PT (P.value <0.05), activated partial thromboplastin time APTT (P.value <0.05), thrombin time TT (P.value <0.05) and fibrinogen level (P.value <0.05). The result show insignificant differences between age groups, sex ,marital status ,and disease types .