Serum lipid Concentration in non-Insolin Dependent Diabetic Patients with Microalbuminuria

Abstract

In this study, fasting blood glucose level, microalbuminuria, triglycerides, total cholesterol, and its lipoprotein fractions HDL and LDL were measured in non- insulin-dependent diabetic patients. 30 non-insulin-dependent diabetic were grouped as follow : • 19 NIDDM patients with microalbuminuria. • 11 NIDDM patients without microalbuminuria were chosen as control. In this study, total cholesterol, LDL, triglycerides were significantly higher in NIDDM patients with microalbuminuria than in NIDDM patients without microalbuminuria. While HDL cholesterol was observed to be normal in NIDDM with and without microalbuminuria. According to the sex differences, females NIDDM with microalbuminuria showed increased levels of microalbuminuria, total cholesterol, triglyceride and LDL which may be due to obesity and lipid imbalance in females compared to males. Elevated plasma glucose observed in the two groups (NIDDM with and without microalbuminuria). This result revealed that levels of total cholesterol, LDL cholesterol and triglycerides increased in NIDDM patients with microalbuminuria, in comparison with NIDDM without microalbuminuria. There was no correlation between microalbuminuria and duration of diabetes. In contrast microalbuminuria correlated positively with total cholesterol, LDL-cholesterol and triglyceride, this show the relation between lipid abnormalities and microalbuminuria and have been thought to play a role in a therogenesis in diabetes.