In Vitro Activity of the Third Generation Cephalosporins Against Pseudomonas aeruginosa

Abstract

This study had been carried out in Khartoum State during period between August 2005 to October 2005. The study evaluate the potency of third generation cephalosporins (Ceftazidime, Ceftraixone, Cefotaxime, cefoprazone) against infection caused by Pseudomonas aerugninosa. Specimens were collected from different hospitals, include Khartoum Teaching hospital 113 (38%), Ear Nose Throat hospital 96 (33%), Military hospital 58 (20%) and National Health laboratory 26 (9%). Different types of bacteria isolated including Staphylococcus aureus 78(28%), Pseudomonas aeruginosa 68(24%), Escherichia coli 49(18%), Klebsiella spp 40 (14%), Proteus mirabilis 38(13%), Citrobacter spp 5(2%), Proteus vulgaris 2(1%). Pseudomonas aeruginosa, isolates were recovered from infected wound 36/68 (53%), infected ear 24/68(35%), and urine 8/68(12%). The study showed that ceftazidime was most effective (91%) followed by cefoprazone (47%), ceftriaxone (7%) and cefotaxime (3%). The results also indicated that the activity of the antibiotics under test against organisms isolated from males and females were 36% and 39% respectively.