Measurement of Some Coagulation Parameters among Women using Oral Contraceptive Pills and Implanon in Khartoum State

Abstract

In spite of various side effects and serious complications associated with the use of combined oral contraceptive pills, it regarded as a safe and highly effective method of contraception. In recent years, the usage of combined oral contraceptive pills with low oestrogen content or without oestrogen are being recommended to minimize the side effects. This analytical case control study was conducted in Khartoum state during the period from June to August 2013. This work aimed to measure some coagulation parameters PT, APTT and fibrinogen level in women using of oral contraceptive pills and implanon. Fifty women were selected as volunteers and considered as case group and other 20 women who didn't use the contraceptive pills or not used implanon were selected as control group. Two ml of venous blood was collected in 0.5ml of 3.8% trisodium citrate containers and investigated for PT, APPT and fibrinogen level by used of coagulameter (clot), the result were analyzed by SPSS. The result revealed that the mean of PT 12.6 seconds, APTT 29.9 seconds and fibrinogen level 261 mg/dL in women using contraceptive pills and the mean of PT 12.9 seconds , APTT 29.9 seconds and fibrinogen level 241 mg/dL in women using implanon. In conclusion the result showed significant decrease of fibrinogen level in women using implanon when compared with control group (P value <0.05). and no significant differences were noticed in PT, APTT and fibrinogen in women used contraceptive pills.