In vitro activity of Cephalexin on Bacterial Urinary Isolates

Abstract

This study was carried out in Khartoum State during the period from October 2003 to December 2005. The study was designed to evaluate the activity of cephalexin by using National Committee for Clinical Laboratories Standard (Nccls) modified Kirby-Bauer Disc diffusion technique against urinary isolates. The total numbers of urinary isolates were 140 species. The species were identified as E. coli 93 (66.4%), Klebsiella spp 20(14.3%), Proteus spp. 12(8.6%), Pseudomonas spp. 10(7.1%), Staph. aureus 3(2.1%) and Strepto. faecalis 2 (1.4%). The results obtained from this study showed that urinary pathogens had high rate of resistant to cephalexin 75 (53.6%), susceptible rate were 34 (24.3%) and 31(22.1%) were intermediate. The study showed that cephalexin had no activity against Pseudomonas spp and was more effective against Staph. aureus (100%) and Strepto. faecalis (100%). The rate of resistance among isolates recovered from males was 59.6% and among isolates recovered from females was 49.4%. Susceptibility rate to cephalexin in females was 25.3% being higher than in males 22.8%. Intermediate susceptibility rate in females was 25.3% being higher than in males (17.5%)