Assessment of Fibrinogen Level and Factor VIII assay among Diabetic Type 2 Patients in Khartoum State

Abstract

Diabetes mellitus (DM) is characterized by high risk of atherothrombotic disorders affecting the coronary, cerebral and peripheral arterial trees .Enhanced activation of the clotting system has been implicated as an important contributing factor for the occurrence of vascular complications in diabetes, the aim of this study is measurement of fibrinogen level and factor VIII assay among diabetic type 2 patient in Khartoum state. This analytical case control study was conducted from (March to June 2013). 30 blood samples were taken from Sudanese diabetic type 2 patients and 30 blood samples from healthy volunteers as controls. Commercial kits of FIBRI PREST ® 2 were used for measuring fibrinogen levels, commercial kits of Helena ® were used for measuring factor VIII assay. Result a significant increase in plasma fibrinogen level (464.37±55.38 mg/dl) and factor VIII (188±22.8 %) in diabetic type 2 patient in comparison with the control group was found and there is a significant positive correlation between plasma factor VIII activity and plasma level of fibrinogen in diabetic type 2 patients. It is conducted that Type2 diabetes mellitus is one of the risk factors of thrombosis and cardiovascular disorder. Clinical and medical strategies should be adopted to control haemostatic changes in type 2 diabetes mellitus patients.