Measurement of Some Hematological Parameters among Patients With Pulmonary Tuberculosis Khartoum State

Abstract

Tuberculosis is a highly prevalent chronic infectious disease caused and it s still a common disease in developed countries and still a major cause of mortality today, can affect many part of the body like lungs and bones this defect can lead to defect most of blood component (Sauders , 2007). The aim of the study is to measure some hematological parameters among Sudanese patients affected with pulmonary tuberculosis in Khartoum state. During the period between April to August 2013 . 40 patients with pulmonary tuberculosis ( 25 males and 15 females) and 20 healthy controls (14 males and 6 females) were included . 2.5 ml of blood was collected from patients and controls into EDTA containers then CBC Test was carried out immediately after collection ,were carried out (Hb, RBCs count, HCT, MCV, MCH, MCHC, TWBCs , platelet count and differential leukocyte count ) using Hematological analyzer (Sysmex KX-21N). Data obtained was analyzed using software program statistical package of social science (SPSS.V.11.5). The results of pulmonary tuberculosis patients when compared with control showed that there was significant lower values in Hemoglobin (Hb), Red Cell Count (RBCs) and Packed Cell Volume (PCV) (P. 0.00) and within the normal range MCV(83.4±2 fl), Mean MCH(30.1±4.3 pg) and MCHC (36.1±1.1 g/dl) in patients compared to controls group . Total leukocyte count (TWBCs) and absolute Monocyte count was significantly increase (P. 0.00) compared to controls group. The absolute Neutrophil count significantly increase in patients (P. 0.008) compared to control group. Most common type of anemia was normocytic normochromic anemia. Significantly increase in platelet count was showed in patients (P. 0.00) compared to controls group. Moderate normocytic normochromic anemia , leuckocytosis especially neutrophilia with monocytosis and moderate thrombocytosis was observed in patients compared to controls group. Absolute eosinophils and basophils count in patient was observed within normal range compared to controls group.