Investigation of the Concentration Goodness for Some Drugs Using Light Angular Scattering

Abstract

In this work a simple setup was build to measure the angular scattering of laser light to test the quality of some medical solutions (concentration) and detect any change in the concentration from the standard concentration which must be suitable for desired dose. In this setup diode laser with wavelength 671 nm and output power 100 mW and photomultiplayer tube were used to find the relation between sample concentration and transmitted intensity at zero angle, and scattered intensities at angles 450,900 and 1350 for the following samples:

Sugar and Sodium Chloride (NaCl) as standard samples, to calibrate the setup and to study the behavior of the scattered light, and other targeted samples: Benzylpenicillin Sodium (BS), Metronidazole and Actrapid HM (Insulin Human) (IH). The results showed that the relation between the transmitted intensity and sample concentration is inverse linear relation. Also, the relation between the angular scattered intensity and sample concentration is linear relation. The study proved that, this setup is very sensitive to detect the scattered laser intensity at any change in sample concentration from its standard concentration. It was found that, a change in the concentration of BS sample, as example by (0.04), the setup gave clear reading of this change. Also, a change in the concentration of (IH) sample by (0.025) gave clear differences in scattered intensity at all angles for this very little change. From the characteristics mentioned above it is clear that, this setup is very efficient in discovering any manipulation in the drug dose.