Evaluation of Serum Cholicalciferol and Cholesterol Levels in Sudanese Women's with Breast Cancer –Khartoum State

Abstract

This is a descriptive cross-sectional study conducted during the period from march to august 2013 in Radio Isotopes Center Khartoum State (RICK), The study, aims to evaluate serum cholicalciferol and cholesterol levels in patients with breast cancer, in addition to correlate Cholecalciferol and cholesterol level with risk factors of breast cancer (age, body mass index, duration of the disease and number of Children birth), sixty patients and thirty healthy individual as control group were enrolled. Venus blood samples were collected and serum obtained using standard procedure. Cholecalciferol and cholesterol levels were carried out using ELISA and Enzymatic method for Cholecalciferol and cholesterol respectively. The results showed, there is significantly decreased in Cholecalciferol level in breast cancer patients compared with control group (P – value (0,000). mean cholesterol level showed significant increased in patients compared with control group (P – value (0.000). menopausal women showed low Cholecalciferol in comparison with premenopausal women (P – value (0,041). And there is no significant difference in the mean of serum Cholecalciferol and cholesterol level in breast cancer classified according to their parity (number of children), body mass index, and duration of disease. The present study conclude that, there was decrease in Cholecalciferol level among Sudanese women with breast cancer especially in menopause one , The mean level of cholesterol was found to be highest in all breast cancer patients. The results of frequencies showed more percentage of breast cancer among postmenopausal women.