Effect of Schistosmiasis on liver Enzymes

Abstract

In this study; urine and feces samples were collected from the children of Jable Aolia locality. Microscopicaly examination for the presence of schistosome eggs were carried out on both samples. Accordingly; the volunteers were divided into two main groups. Control group that contains children negative for both types of bilharsiasis and the target group which contains children found to be positive for bilharsiasis. The latter group is further subdivided into two groups; urinary and intestinal bilharsiasis. Then blood samples were withdrawn from the three groups and liver enzymes were measured using COBAS INTEGRA 400 plus. When result of liver enzymes for the patients (regardless schistosomiasis type) were compared with the control group; significant variations were observed in ALP, AST and GGT; p values are 0.005, 0.000 and 0.006 respectively. When result of liver enzymes for the patients (two sub groups) were compared with the Heamatobium control group; significant variation was found in ALP results between the control group and heamematobium schistosomiasis p value is equal to 0.039 but no significant variation was observed between control group and mansoni schistosomiasis; p value 0.127 and also no significant variation found between the two types of schistosomiasis; p value 0.906. however no significant variations were found for ALTS result between the control group and heamematobium schistosomiasis, control group and mansoni schistosomiasis, and between the two types of schistosomiasis. P values were 0.814, 0.939 and 0.938 respectively. For AST, Significant variation were found between the control group and the two types of schistosomiasis, P value was found to be 0.000 between the control group and heamematobium schistosomiasis while p value was found to be 0.009 between control group and mansoni schiosomiasis. No significant varation was observed between the two types of schistosomiasis p value 0.865. Regarding GGT, Significant variation were found between the control group and heamematobium schistosomiasis p value is equal to 0.001 and significant variation was observed between control group and mansoni schistosomiasis p value 0.054. And also significant variation was found between the two types of schistosomiasis p value 0.033.