Relationship of Serum Levels of Magnesium and Urate to Creatinine and Duration of Disease in Sudanese Patients with Chronic Renal Failure

Abstract

A cross-sectional study conducted during the period November 2008 to June 2009, compared serum levels of magnesium, urate and creatinine of 50 Sudanese patients with chronic renal failure (CRF) (as a test group), and 30 apparently healthy volunteers (as a control group). Participants in this study were from Dr.Salma Center for Kidney Transplantation and Dialysis, Ibn Sina Hospital and Ibrahim Malik Teaching Hospital. Age and gender of the test group were matched with the control group. The serum levels of magnesium, urate and creatinine were measured using, Biosystem BTS-310 analyzer, Germany. Serum magnesium, urate and creatinine were significantly raised in the test group compared to the control group. Mean ± SD for the test group versus the control group: (2.22 ± 0.20) versus (1.90 ± 0.14) mg/dl (p = 0.03); for serum magnesium. (6.12 ± 1.52) versus (4.17 ± 1.32) mg/dl (p = 0.01); for serum urate. (9.45 ± 3.77) versus (0.83 ± 0.16) mg/dl (p = 0.001); for serum creatinine. In the test group, serum magnesium, urate and creatinine showed no correlation with the duration of the disease (r = 0.00). Serum magnesium and urate showed a weak positive correlation with serum creatinine (r = o.35) (r = 0.33) respectively. From this study, it is concluded that; in Sudanese patients with CRF the serum levels of magnesium, urate and creatinine were raised. In addition, serum magnesium, urate and creatinine are not correlated with the duration of CRF, whereas serum magnesium and urate are weak positively correlated with serum creatinine.