Evaluation of Ovarian Cancer Response to Radiotherapy by Using Ovarian Cancer Antigen CA-125 As a parameter

Abstract

Ovarian cancer is common cancer in Sudanese women and it’s the fourth most common cause of cancer death among women after cancer of the breasts, lungs and bowel. Therefore evaluation of cancer response to treatment it’s crucial. Hence the main objective of this study is to evaluate this cancer response to radiotherapy by using tumour marker called ovarian cancer antigen (CA 125) in order to be able to screen for and diagnose ovarian cancer early, when it’s most treatable and before it has the chance to grow and spread .The data of this study was collected from 60 women attending to RICK (Radiation and Isotope Center of Khartoum ) divided in two groups the first group include 20 normal healthy women which selected as a control group and for determination of the normal range of CA 125 and we found the average of this group is about 13.6 which corresponds to the international range (0--35 UI/ml ) and the second group contains 40 patients diagnosed confirmed histopathologically as cases of ovarian cancer. The procedure done by taking 3cc (3ml) of venous blood from each subject and then use this technique for estimating the level of this tumour marker. It is proved that the value of this tumor marker is very high in samples collected from ovarian cancer patients. The study showed that the level of CA 125 goes down after having radiotherapy. The researcher noted that the mean value of this antigen before radiotherapy was 208.7 (which is very high) and goes down during radiotherapy until the average reaches 65.6, and continuous in reduction until it reaches the international standard level of 17.9, after finishing the treatment by one week. Beside the study results connected with patient’s age and the stage of the disease. The Researcher found that it may be directly proportional to both of them.