Comparative study of 99mTc MAG3 and 99mTc DTPA Radiopharmaceuticals in Detection and Evaluation of Hydronephrosis

Abstract

Renal scintigraphy using 99mTc-diethy-lenetriamine pentaacetic acid (DTPA) or mercaptotriglycine (MAG-3) with administration of frusemide in (diuretic renography) is used to estimate absolute and differential renal function in different pathological conditions; Nuclear Medicine Scintigraphy has provided a unique tool for the noninvasive evaluation of renal pathophysiology. Hydronephrosis is one of endemic diseases in Sudan which can affect the kidneys in both short and long time intervals leading to renal failure in future. The aim of this study was to evaluate the use of quantitative T ½ value in detection of obstructive and non-obstructive hydronephrosis using both radiopharmaceuticals (99mTc-MAG3 and 99mTc-DTPA) and to define the T ½ ranges of each Type of (HyN) in Sudan, and to find out the radiopharmaceutical of the choice in detection of hydronephrosis, Between Jan 2009 and November 2009, 100 patients suffering of hydronephrosis divided into two groups in two different hospitals (RICK,ELNILINE), each group (50 patient) of patients were injected with different radiopharmaceutical (group 1 with 99mTc-MAG3 in RICK) and (group 2 with 99mTc-DTPA in ELNILINE), The Standardized diuretic renograms were obtained in nuclear medicine centers T ½ ranges for obstructive (HyN) were the range of (<12min) and for Non-obstructive (HyN) were in the range of (<8-12). Drainage half-time clearance (T ½) were lower in all the cases of (HyN) injected with 99mTc-MAG3 than cases been injected with 99mTc-DTPA, which make it the radiopharmaceutical of the choice in detection of (HyN).