Evaluation of Haemostatic Mechanism Among Pregnant Women in Khartoum Teaching Hospital

Abstract

This is a cross- sectional descriptive and analytical study, conducted at Khartoum Teaching Hospital during the period from first of November 2009 to June 2010. The aim of this study was to estimate the platelet count, Prothrombin time and partial thromboplastin time tests in Sudanese pregnant women who were referring to Khartoum Teaching Hospital (Obstetric Ward). The study included seventy six (76) Sudanese females, 60 were and 16 were non pregnant. The 60 pregnant women who were apparently in good health were informed about the study and their consent for participation was obtained. The study population was divided into three groups according to the trimesters (first trimesters, second trimesters and third trimesters) each had the same number 20 pregnant women. As for the 16 non pregnant females samples were taking for the purpose of comparison. Venous blood sample of five ml was taking (2.5 ml in EDTA containers and 2.5 in tri sodium citrate containers) 2.5 ml EDTA investigated for platelet count, and 2.5 tri sodium citrate for Prothrombin time and activated partial thromboplastin time tests. Fully automated hematology analyzer (Sysmex) was used for platelet count and manual analysis for PT and APTT tests. All pregnant women had mean values of platelet 215.4 X10 9/l, PT = 12.8 seconds and APTT = 34.1Second compare with non pregnant women table The results indicated that for pregnant women who were given the medical drugs ( folic acid ,fefol ) the platelets slightly decreased significant (P = 0.038) in comparison with those who did not take supplement .where as the PT(P = 0.394), and the aPTT(P =0.546) were normal and consequently do not have significant values. The results also showed that there was a decreased in the platelets count in all trimesters, in comparison with control. While PT was within normal range , for the aPTT the results showed a slight increase during three trimester and so it is insignificant, that is to say it is more than >0.05 .