Fibrinogen Level Among Sudanese Smokers With Reference To Duration of Smoking and Number of Cigarettes

Abstract

This is a cross-sectional descriptive and analytical study, conducted at Khartoum state during the period from March 2010 to May 2010 . the aim of this study was to estimate the fibrinogen level in Sudanese smokers who attended Khartoum state .fifteen apparently healthy nonsmokers and fifty Sudanese apparently healthy smokers were informed and agree to participate in the study. The smokers were divided in to three groups according to the duration of smoking or number of cigarette per day as follow: According to duration of smoking the first group were smoking for less than 10 years, the mean of fibrinogen level recoded 2, 88 g/l in this group, while the second group were smoking between 11 to 20 years, the mean of fibrinogen level recorded 5,63g/l .the last group were smoking for more than 21 years, the mean of fibrinogen level recorded 7,1g/l. According to number of cigarette per day the study population were divided also in to three group, the mean of fibrinogen level was 3,08g/l in the first group who smoked less than 10 cigarette /day 6,02 in the second group who smoked from 11to 20 cigarette /day ,and 6,97 in the last group who smoked more than 21 cigarette /day. The samples investigated by using the Sysmex automated blood coagulation analyzer CA500 to estimate the fibrinogen levels. The results indicated that fibrinogen level was within the normal range in the first groups according to intensity and duration of smoking. But in comparison with control groups, fibrinogen levels were statistically higher. While fibrinogen levels were abnormally and significantly higher in the others groups in comparison to the control group, p value <0.005. The correlation between the number of cigarette and duration of smoking indicated high correlation with fibrinogen level. (P.value < 0.001).