Evaluation of Haemostatic Mechanisms in Sudanese Patients With Gastrointestinal Bleeding

Abstract

This study was carried out at Mohammed Salih Idres center for gastrointestinal bleeding during the period from January to feb 2010, prothrombin time (PT), activated partial thromboplastin time (APTT) and platelet count were measured to 50 gastrointestinal bleeding patients, 43 were males (86%) and 7 females (14%) with mean age 47 years, compared with 30 healthy individual as control group. All sample were analyzed to determine the effect of GI bleeding on coagulation and correlate coagulation parameters investigated to age, gender and causes of GIT bleeding. The results showed that PT was significantly prolonged in patients than controls (P=0.00), APTT was slightly prolonged in patients (P=0.05) and platelet count was significantly decreased in patients than control (P=0.00). Patients with oesphagus variances were having a normal intrinsic and extrinsic pathway and platelet count; Patients with portal hypertension were having a decrease platelet count only, and Patients with other causes of GIT bleeding were having a defect in the intrinsic and extrinsic pathway and decrease in platelet count. No statistically significant correlation was found between coagulation parameters investigated and gender and age in those patients.