Evaluation of Haemostatic Mechanism associated with liver disease among Patient Attending Khartoum teaching hospital

Abstract

This study was hospital analytical case control, and it was conducted for evaluate of haemostatic mechanism among the Sudanese patient with liver diseases attending Khartoum teaching hospital throughout the period betweenNovember2009– March2010. Forty patients were informed about the study, expected out come and agreement of participation was obtained, then the questionnaire was used to collect the information about patient's age, sex, blood groups as well as other diseases. As well 5 ml of blood were taken from the patients 2.5 ml of which were taken in heparin anticoagulant, and the remaining 2.5 were taken in EDTA anticoagulant and were used to evaluate the haemostatic mechanism (Prothrombin Time, Activated Partial thromboplastin, Platelets counts). The mean age of patients having liver diseases was 49 years. The liver disease patients include two gall choleystitis (5%), five obstructive jaundice (13%), ten liver cirrhosis (25%), fifteen HBV (38%), six HCV (15%) and two liver metastasis (5%). The values of PT, APTT, INR and Platelet of the liver diseases patient were (17.5), (39.8), (1.5) and (151.8) respectively. The PT values in Liver cirrhosis, HBV, gall cholecystitis and obstructive jaundice were higher compared with control; P.value was < 0.008, <0.08, <0.000 and <0.03 respectively. The APTT values in HBV, obstructive jaundice, HCV and liver metastasis there were higher compared with control, P.value were< 0.002,< 0.000, <0.04 and< 0.003 respectively. The Platelet count values in Liver cirrhosis, HBV and HCV there were higher compared with control P.value were< 0.000, <0.000 and< 0.007 respectively. Lastly the PT-INR in Liver cirrhosis, gall cholecystitis, obstructive jaundice and HCV there were higher compared with control P.value were< 0.01, < 0.003, < 0.03 and < 0.008 respectively. In conclusion the haemostatic mechanism is extremely affected as results of liver diseases.