Study of Cytomorphological Pattern of Urine Among Renal Transplant Patients Attended Dr. Salma Center For Kidney Diseases And Sudanese Association for Renal Transplant

Abstract

Urine cytology is useful in the diagnosis of urinary tract infections, some cancers, and other diseases. Those benefits are useful for renal transplant patients due to infections and cancers as a result of prolonged immunosuppressant. This study carried out in December 2009 to July 2010 at Dr. Salma center for kidney disease and Sudanese association for renal transplant. The study aimed to demonstrate the cytomorphological changes in the urine of renal transplant patients. Cytological changes were investigated among 182 patients aged between 13-71 years. Full voided urine samples were collected. The smears were prepared, fixed and stained with Papanicolaou stain, then examined and evaluated. The following was found; 123(67.6%) without pathological abnormality, 45(24.7%) bacterial infections, 2(1.1%) candida infections, 2(1.1%) actinomyces infection, 3(1.6%) BK polyoma virus infection, 2(1.1%) both BK polyoma virus and HPV infection, 2(1.1%) human papilloma virus (HPV) infection, 1(0.5%) HPV and Candida infection, 1(0.5%) HPV infection and dyskaryosis and 1(0.5%) dyskaryosis. The result agree with other research, in that renal transplant patients more susceptible for infectious disease, infection with HPV and BKV is related to sex (0.001) and the patients receive Taclorimus more susceptible to get BK infection(P.value=0.006). From all the study conclude that the bacterial infections are the most common finding, Renal transplant patients with high risk for Bk polyoma virus and Human papilloma virus. Study suggests systemic cytological screening for patients which is useful in early detection of disease.