Evaluation of the Effect of Chemotherapy in Hematological Parameters among Leukemic Patients in Sudan

Abstract

The current study is a non-experimental hospital base case control study, conducted at Radiation & Isotopes Center- Khartoum (RICK) during the period November 2009/April 2010. The study aimed to evaluate the effect of chemotherapy in some hematological parameters among leukemic patients who referred to the Radiation & Isotopes Center – Khartoum. People recruited for this study were 50 leukemic patients. (35 males and 15 females). Their age ranged from 16 to 85 years with mean age of 49 years. Thirty- five patients were suffering from deferent types of leukemia (16 patients had acute myeloid leukemia AML, Three patients had acute lymphoblastic leukemia ALL, Four patients had chronic myeloid leukemia CML and 12 patients had chronic lymphoblastic leukemia CLL) received chemotherapy and the remaining 15 patients did not start treatment and were used as control. Blood sample were collected from all patients (50 study subject).The blood samples were investigated for Hb, PCV and total RBCs count, WBCs & Platelets count. Using Sysmex automated hematology analyzer. The results obtained from blood analysis of patients that received chemotherapy were compared with those from patients who did not start treatment, and are as follows: There was significant (P>0.05) reduction in Hb and total RBCs count in patients who receive chemotherapy as compared to control patients who did not start treatment. There was significant (P>0.05) decrease in total platelet count in patients who receive chemotherapy as compared to control patients who did not start treatment. There was significant (P>0.05) increase in total WBCs count in patients who receive chemotherapy as compared to control patients who did not start treatment. The result obtain from the current investigation are highly suggestive that patients under chemotherapy are at risk of anemia and bleeding problems.