Evaluation of hemostatic mechanism in Sudanese renal failure patients attending Khartoum teaching hospital

Abstract

This study was conducted at Khartoum Teaching Hospital (Renal dialysis Unit) in the period between 12/2009-2/2010 in order to assess the coagulation mechanism into two clinical groups, acute and chronic renal failure patients. individual recruited for this study include 40 patients (8 acute renal failure and 32 chronic renal failure , of them were 28 males and 12 females) of a mean age of 40.6 years and 14 healthy individuals considered as control. Among those patients, there were 15 hypertensive, 2 diabetics, and 4 Hepatitis C virus. Blood samples were collected from both patients and controls and used for laboratory investigations of activated partial thromboplastin time (aPTT) , prothrombin time (PT) , and platelets count using routine methods. The results of this study showed prolongation of PT and aPTT and a decrease in platelet count compared to the control ,the difference was statistically significant in platelets counts of chronic cases (p<0.001). In renal failure that associated with other diseases, the results showed a prolongation in the PT and the aPTT, the prolongation was significant only in patients with hepatitis C (p<0.007). The platelet count was significantly decreased in all cases associated with renal failure (p< 0.05). The present work concluded the renal failure patients are at high risk of bleeding due to thrombocytopenia ,platelets disfunction . And venous thromboembolism due to loss of antithrombinIII ,factor IX ,XII ,and prekalkrein , and decreased of protein C activity.