Assessment of serum Testosterone and PRL Levels among Males Chronic Kidney Disease Patients in Khartoum State

Abstract

Background: chronic kidney disease is recognized as a major health problem standing the community over years. Furthermore, it affects most population under different aging with prevalence between 11% - 13% globally and 5%-7% in Sudan. Additionally, it is defined by persistent urine abnormalities, structural abnormalities or impaired excretory renal function suggestive of loose of functional nephron. Hence, the aim of this study was to investigate the association of the serum testosterone and Prolactin hormones in patients with chronic kidney disease. Methods: This case control study was conducted at Alturkey hospital and Ultra lab with in three months from September 2018 to November 2018, the study carried out on a total sample of 80 including 40 chronic kidney disease patients as case and 40 healthy individual as control group. Serum prolactin levels was estimated using Enzyme linked immune sorbent assay technique and serum testosterone level was estimated using TOSOH AIA 1800 system analyzer. Data analyzed using SPSS soft ware program version 21. Results: This study showed that the levels of testosterone was significantly decreased with (p-value 0.000); while there was significant elevation in level of prolactin with ( p-value 0.000) in Chronic Kidney Disease patients compared to control group. When comparing Chronic Kidney Disease patients according to Diabetus Mellitus , presence of hypertensions and take of medication the study showed that there was significant increase in prolactin and significant decrease in testosterone in diabetic patients compared to non diabetic patients with (p-value 0.038, p-value 0.033) respectively and there was insignificant difference between hypertensive & non hypertensive in the level of prolactin and testosterone in chronic kidney disease patients with (p.value 0.066 p.value 0.440) respectively, also there was insignificant difference between patients had taken medication and V no taken medication in the level of prolactin and testosterone in chronic kidney disease patients with (p.value 0.620 p.value 0.267) respectively. There was no correlation between testosterone levels with duration, and body mass index (R -0.064 P.value 0.694, R -0.088 P.value 0.588) and negative correlation with age (R -0.562 P.value 0.000) respectively. Also, there was positive correlation between prolactin with duration and body mass index with (R0.726 P.value 0.000 ** R 0.639 P.value 0.000) respectively and no correlation between prolactin and age with (R 0.158 P.value 0.331). Conclusion: this study concludes that, the patients with Chronic Kidney Disease have high prolactin and low testosterone