Estimation of D-dimer Level among thyroid abnormalities Sudanese Women at Omdurman locality

Abstract

Background; Thyroid disorders represent an important public health problem worldwide ranking second to diabetes as the commonest endocrinological disorder seen in adult medical practice and presenting a myriad of devastating consequences if not treated early. This study aimed to estimate the D-dimer levels in hyperthyroidism and hypothyroidism femaleunder treatment. Materials and Methods; A descriptive cross sectional study obtained at Omdurman Military hospital and Asia Hospital during the period of (February - July 2017), the practical done in Omdurman Military Hospital. 4.5 ml of venous blood collected from 60 thyroid dysfunction volunteers placed in 3.2% tri sodium citrate container then centrifuge to get platelet poor plasma (PPP).D-dimer was estimated using Ichroma™ D-Dimer and all data was analyzed by SPSS version11.5. Results; .The mean of D-dimer in hypothyroidism 280ng/ml and mean of D-dimer in hyperthyroidism 246ng/ml. The study showed that no significant difference in D-dimer in hypothyroidism and hyperthyroidism volunteers (p.value=0.4) and no correlate between D-dimer and TSH, T4 and T3 in both study group (P. values 0.66, 0.92 and 0.89) respectively. The result showed that weak positive correlation between D-dimer and age group in hypothyroidism patients(p.value= 0.01, r= 0.43) and hyperthyroidism patients (p.value= 0.02, r= 0.41), also there was no significant difference in D-dimer according to BMI and duration time of disease in hypothyroidism patients (p. value ,0.7and 0.5)and hyperthyroidism patients (p. value ,0.7and 0.9)respectively. Conclusion; Sudanese female with thyroid dysfunction presented normal D-dimer.