Assessment of Albumin / Creatinine Ratio in Sudanese Hypertensive and Hypertensive Diabetics Patients in Khartoum State

Abstract

Background: Hypertension (HTN) is a noteworthy public health concern worldwide due to its significant contribution to the global health burden. It increase risk of serious problems such as heart attacks, strokes, vascular disease and chronic kidney disease. Objectives: This study done to assess albumin/creatinine ratio in Sudanese hypertensive and hypertensive diabetics Patients in Khartoum state. Material and method: The study carried out at Khartoum state in Sharg Alneel hospital, during the period of March to October 2018, including 66 participants and 34 of them are hypertensive (as case) and 32 non hypertensive (as control) measurement of albumin-to creatinine ratio (ACR) in a random urine sample was done for all participants by Roche COBAS and data were analyzed using SPSS in computer program. Results : Albumin/creatinine ratio was high significant elevated in cases (85.5±22.7 mg/g) when compared to controls (8.4±3.6 mg/g) with p value 0.00, highly significant increased in albumin/creatinine ratio in hypertensive with diabetes mellitus (129.4±31.61 mg/g) when compared with hypertensive without diabetes(50.9±18.24 mg/g) with p value 0.00 , insignificant different of albumin/creatinine ratio in male (94.11±49.43 mg/g) when compared to female (75.95±42.64 mg/g) with p value 0.263 and significant positive high correlation with age(r= .735 p=0.00) and significant positive moderate correlation with duration of hypertension(r= .685 p=0.00). Conclusion: This study revealed that albumin/creatinine ratio was increased in hypertensive patients, hypertensive with diabetes mellitus, and the increase was associate with age and duration of hypertension while not associate with gender.