Measurement and Evaluation of Troponin T and Lipid Profile in Hypertensive Patients in Khartoum State

Abstract

Background. Cardiac troponin T (cTnT) is a cardiac regulatory protein that control the calcium mediated interaction between actin and myosin, TnT is a component of the contractile apparatus of the striated musculature. As a result of its high tissue-specificity, cardiac troponin T (cTnT) is a cardio-specific, highly sensitive marker for myocardial damage. Objective. This study aimed to measure and evaluate the usefulness of Troponin T and lipid profile in hypertensive patients who had developed chest pain due to cardiac event . Subjects and Methods. Cardiac troponin T(cTnT) and lipid profile were measured with a quantitative laboratory methods for one hundred hypertensive patients and 100 apparently healthy subjects as a control group. Cardiac troponin T was measured by Elecsys 2010 and lipid profile were measured by enzymatic method. Results. The results of this study revealed a significant elevation of troponin T and HDL-C levels in hypertensive patients and also showed a significant correlation between troponin t and total Cholesterol ( P value= 0.001, R = 0.341) , there was a significant increase in the levels of troponin T and HDL cholesterol (p<0.05) in hypertensive patients as compared to those in the healthy controls. On applying Pearson’s correlation, in hypertensive patients there was significant correlation between Troponin T and total TC ( P- value= 0.001, R = 0.341) , Troponin T and Triglyceride ( P- value= 0.029,R = 0.218) , Troponin T and LDL (P- value =0.002 ,R = 0.309) , duration of disease and Troponin T (P-value 0.038 ,R = 0.208) , duration of disease and TC (P-value=0.041, R=0.205) , duration of disease and LDL (P- value= 0.017 , R = 0.238), systolic blood pressure and troponin T (P-value= 0.011 ,R = 0.254), systolic blood pressure and LDL (P-value=0.032, R=0.215), diastolic blood pressure and TC (p-value=0.010, R=0.257) and diastolic blood pressure and LDL (P-value=0.010, R=0.250). A significant correlations between Trooponin T and HDL, body weight and Troponin T, body weight and TC, body weight and TG, body weight and HDL, body weight and LDL, duration of disease and TG, duration of disease and HDL, systolic blood pressure and TC, systolic blood pressure and TG, systolic blood pressure and HDL, diastolic blood pressure and troponin T, diastolic blood pressure and TG and diastolic blood pressure and HDL, P- value >0.05 for all, which were statistically not significant. Conclusion. This study confirms that the cardiac troponin T can be used as a predictor for the early detection of cardiac event along with the lipid profile markers in hypertensive patients .