Estimation of Fibrinogen Level in Umbilical Cord Blood among Gestational Diabetes Mothers

Abstract

Background: Gestational diabetes mellitus (GDM) is the most common medical complication of pregnancy. It is associated with maternal and neonatal adverse outcomes. Fibrinogen level has been the intensive study in latest years. In addition, there is an association mentioned in previous records between fibrinogen level and newborn metabolic diseases, liver disorders and some cancers. Objectives: To evaluate and estimate fibrinogen level in newborn cord blood of gestational diabetes mellitus mothers from February to August 2018, and to compare with fibrinogen level of newborn cord blood of healthy pregnancy. Moreover, to correlate fibrinogen levels according to the gestational weeks and weight of newborns. Materials and Methods: A case control study was conducted on 60 newborns from 30 mothers with GDM and 30 healthy mothers after ethical consent and hospital approval. Citrate cord blood samples were performed for fibrinogen estimation. Results: There were statistically significant increase of fibrinogen level (P.value=0.026) among newborns with GDM mothers (257.66±32.61mg/dl) compared with control group (236.77±37.93mg/dl). And there was significant increase in fibrinogen level in newborns with mothers FBG<100 mg/dl (249.44 mg/dl) compared with mothers FBG>100mg/dl (231.33 mg /dl) (P. value=0.031). No correlation between mentioned level and gestational weeks (P. value=0.414) and also the weight of newborns (P. value=0.401). Conclusions: There were significant increase of fibrinogen level among newborns with GDM mothers and no correlation between mentioned level and gestational weeks and also the weight of newborns.Increased fibrinogen level may contribute to the development of thrombotic risk.