Measurment of Some Coagulation Profile and Platelets Count in Patients of Open Heart Surgery in Sudan Cardiac Center -Khartoum State 2011

Abstract

This is hospital bass cross sectional analytical study in Sudan cardiac center (Khartoum State) during the period March to July 2011 .In Open heart Surgery Patients to evaluate routine coagulation profile and platelets count. Open heart surgery patients were selected for this study 50 blood sample were collected before surgery and 50 sample were collected after surgery to evaluate coagulation profile by manual methods and platelets count by sysmex automated method. The gender distribution showed that male 33 (66%) and female 17 (34%) Prothrombin time pre surgery was seconds with significant were 15.37 seconds, and post surgery was 21.84 difference ( P. value .000 ) . Activated partial thromboplastin time pre surgery was 35.08 seconds and post surgery was 42.74 seconds with significant difference ( P. value 0.001) . Platelets count pre surgery was 231.92 , and post surgery was 216.86 with significant difference ( P. value 0.001). All the coagulation profile showed prolongation , platelets count decreased from the count pre surgery .The reduced amount of coagulation factors after surgery due to exposure of the patients blood to cardiopulmonary bypass circuitry diminishes the hypercoagulable state and proceeds into an imbalanced hypocoagulable phase as conclusion open heart surgery were effected the haemostatic mechanism in both male and female the ( PT,INR, APTT ) showed . significant prolongation and platelets count showed significant decrease