Role of haemodialysis on Prothrombin Time, Active Partial Thromboplastin Time, and D dimer in Late Stage Renal Failure Patients

Abstract

This study was conducted in Dr. Salma Center for hemodialysis in Khartoum from January to June 2010. The objective of this study is to determine effect of hemodialysis as risk factor of thrombosis in end stage renal failure patients. Samples were collected randomly from 50 patients under haemodialysis. Blood samples were collected, 2.5 ml in citrate anticoagulant and analyzed by automated blood coagulation analyzer for measurement of PT and APTT by seconds and D- dimer Redder II to measurement D-dimer concentration by mg/L compared to normal control. The results showed that suffering from risk of 14% of the patients were thrombotic embolism with concentration of D-dimer >0.3mg/L in D dimer and 86% were normal, 62% of patients under dialysis were male, while 38% females and the mean age was 43 years old. Also showed that there was insignificant difference in PT which 16.1 sec with P.value (0.173), and significant difference in APTT which 73.8 sec with P.value (0.000), D dimer level was 2.26mg/L with P.value (0.012). PT, APTT, and D dimer level were increased with increasing of duration of dialysis, but the difference was statistically insignificant. On the other hand increasing age of patients lead to increase possibility of thrombosis significantly by an increase of D dimer concentration, but insignificantly in PT and APTT. Finally there was significant differences in APTT in patients were treated with recombinant erythropoietin and iron supplement, but the difference was insignificant for PT, and D dimer concentration.