Assessment of Total Serum Prostate Specific Antigen (TPSA), Anti Mullerian Hormone (AMH) Level among Sudanese Women with Polycystic Ovarian Syndrome (A study in Khartoum State)

Abstract

Back ground: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorders in women of reproductive age group, cause of androgen excess in women. (PSA) may be a new one diagnostic tool for PCOS. Serum AMH is synthesized by small antral follicles, which are precisely those seen on ultrasound and could help us to diagnose PCOS. The aim of this study to evaluate the levels of serum TPSA, AMH among Sudanese women with polycystic ovary syndrome and to determine the performance of PSA in diagnosis of PCOS. Material and Method: In a cross sectional case control study, 50 women newly diagnosed with polycystic ovary syndrome and 50 apparently healthy controls were enrolled. Sample were collected during the period between February to May 2017 from Elsir Abo Alhassen Center for Infertility in Khartoum State, serum TPSA , AMH levels were measured using an ultrasensitive method (Electrochemiluminesent (ECL) immunoassay method) . Results were analyzed using statistical package for social science (SPSS) computer program. Result: Serum levels of TPSA, AMH were significant higher in polycystic ovary syndrome group versus control group with mean ± SD for TPSA (0.019 ±0.009 ng/ml) versus control group (0.001 ± 0.001 ng/ml) and a p.value=0.00. AMH was (14.11±9.2 ng/ml) versus control group (2.404 ± 1.00ng/ml) p.value 0.00. There was a slight decrease in level of TPSA in females who had regular cycle in contrast to females that had irregular cycle with p.value = 0.04, where there was no difference in AMH p.value = 0.6. Also, this study showed that there was positive correlation between TPSA and BMI (P.value=0.00, r=.893) and negative correlation between AMH and BMI (P.value=0.025, r = -.317). The majority of females had irregular cycle were obese 36%, the overweight were 24% and those with normal weight were12%. Also there was significant increase in TPSA and AMH in PCO patients who had family history, TPSA (mean+ SD 0.022 ± 0.021 ng/mL versus 0.0165±0.006 ng/ml) pvalue 0.03, and AMH (mean+ SD 21.3±10.0 ng/ml versus 10.6± 5.6 ng/ml) p value 0.00. Conclusion: The study concluded that the serum levels of TPSA, AMH are increased in PCOS. TPSA and AMH were significantly increased in patients who had family history.