Assessment of Serum Gamma Glutamyl Transferase and Albumin levels among Patients with Tuberculosis under Treatments

Abstract

Tuberculosis still a major problem in Sudan and the anti tuberculosis drugs continue to be problematic in a systemic manner, which affect the liver leads to hepatotoxicity and elevation of liver parameter . The aim of the study to determine the levels of albumin and GGT in patients with tuberculosis under treatment and compare the level of albumin and GGT according to sex and type of drugs. This study was conducted at Kassala state during April to July 2017. In this study eighty blood samples were tested, sixty samples from known patients with TB under treatment and twenty control samples. The study demonstrated that albumin was significantly decreased among TB patients under treatment compared to control group (Mean±SD: 2.96±0.48g/dl) for cases and (Mean±SD:4.45±0.59 g/dl) for control group with P.Value 0.000 . GGT was significantly increased among TB patients under treatment compared with control group (Mean±SD:87.60±39.29IU/L) for cases (Mean±SD:17.00±3.45 IU/L) for control group with P.Value 0.000 . Also the finding of this study showed that albumin was significantly decreased in patients under medication with rifampin compared with control group ( Mean ± SD: 3.17± 0.48 g/dl) for cases and (Mean±SD:4.45±0.59 g/dl) for control group with P.Value 0.004. Also albumin show significant decrease in patients under mixed medication with rifampin and ethumbutol compared with control group (Mean±SD:2.73±0.30 g/dl) for cases and (Mean±SD:4.45±0.59 g/dl) for control group with P.Value 0.007.Albumin also show significant decrease in patients under mixed medication with rifampin, ethumbutol and pyrazinamide compared with control group ( Mean ± SD:2.81 ±0.45 g/dl ) for cases and (Mean ± SD :4.45±0.58 g/dl ) for control with P.Value 0.006 . GGT showed a significant increase in all patients using different (single or mixed) types of TB treatment (RIF, RIF+EMB, RIF+EMB+PZA), P.value (0.004, 0.000, 0.001) respectively. It is concluded that: using Rifampin and Ethumbutol together for treatment of TB lead to significant changes in albumin and GGT levels.