Immunohistochemical Detection of CD56 in Thyroid Tumors Among Sudanese Patients

Abstract

This is hospital based analytical retrospective case control study conducted in Omdurman teaching hospital during the period from may 2017 to august 2017 aimed to detect CD56 in thyroid tumors among Sudanese patients. A total of 40 formalin fixed paraffin blocks previously diagnosed as thyroid tumors were selected 20(50.0%) samples were papillary thyroid cancer, 5(12.5%) samples were follicular carcinoma, 5(12.5%) samples were follicular adenoma, 5(12.5%) samples were goiter and 5(12.5%) samples were lymphothyroiditis. One section of three micron was cut from each block and stained by immunohistochemical method (avidin biotin technique) for CD56 detection. The data obtained was analyzed using SPSS computer program version 13. The patients ages ranged between 11 to 70 years with mean age 45 years, most of patients 27(67.5%) were less than 50 years and the remaining 13(32.5%) were above 50 years. Patients sex revealed that 8(20%) patients were male and 32(80%) were female. Positive expression of CD56 was detected in 5/25 samples and negative in 15/25 samples of malignant samples, while all benign samples showed positive expression 15/15 samples (P. value 0.000). The study concluded that the expression of CD56 increase in benign thyroid tumor more than malignant thyroid tumor.