Determination of Morphological and Physiological patterns of anaemia among Sudanese Patients with Gastro Intestinal bleeding In Khartoum state

Abstract

A hospital-based analytical descriptive study was conducted in Mohammed Salih Idress center from March 2011 to June 2011, to determine the morphological and physiological patterns of anemia among Sudanese patients with Gastro intestinal bleeding Hundred Gastro intestinal patients were those who fulfilled the clinical diagnosis of Gastro intestinal bleeding of both gender , from different region of Sudan and different tribe ,were informed about the study expected out come and agreement of participation was obtained. The controls were normal not receive any treatment or transfusion in their life. A structured questionnaire was used to collect information about patients age, gender, tribe, blood vomiting, passing of black stool, history of bilharziasis , present of splenomegaly and hepatomegaly, and laboratory investigations. Blood sample were collected from all patients and controls for use in laboratory investigation. Statistical package for social science (SPSS version 11.5) computer software was used for data analysis. The results showed significant difference between the mean level of patients and control in the following parameters haemoglobin level, hematocrite, RBCs count, TWBCs, platelet count and RBCs indices (p. value< 0.05). The study explained that the patterns of peripheral blood picture among study group 46(46%) were normocytic normochromic type and consider to be highest prevalence morphological type of anemia among Gastro intestinal patient, 30(30%) were microcytic hypochromic comes in second class and 24(24%) were dimorphic picture. Reticulocytes was significantly increase in compared to control group (p.value <0.05) The result showed significantly decrease in the mean level of haemoglobin , hematocrite, RBCs count, platelet count and RBCs indices among Chronic and acute gastro intestinal bleeding patients compared to control group(p.value <0.05) The results showed insignificant difference between Mean Cell volume,Mean cell haemoglobin and Mean cell haemoglobin concentration.in patients with normocytic normochromic RBCs and control group(p.value>0.05),while they showed significantly decreased in patient with microcytic hypochromic RBCs and with dimorphic picture (p.value < 0.05).