Alteration in Platelet Count and Platelets Indices in Type 2 Diabetes Mellitus in Sudanese Patients -Khartoum State

Abstract

This is a case control study carried out in Al-ribat Medical Specialize Complex- Khartoum State during February 2017 to April 2017,, to evaluate the alteration in platelets count, mean platelet volume (MPV/ fl), platelet distribution width (PDW/fl ) plateletcrit(PCT/%) and platelet large cells ratio(P-LCR%),in Type 2 Diabetes Mellitus Sudanese patients .Sixty diabetics and sixty healthy individuals were enrolled in the study after taking their verbal consent. Venous blood (2.5ml) was collected from the participants in EDTA containers and gently mixed. Platelets count and Platelets indices were determined by an automated sysmix ( KX-21) technique and HbA1c by Ichroma. The obtained data were analyzed by both Student's Independent T test and One Way ANOVA test using SPSS version 16 computer program. The platelet count C/cmm, MPV/fl and PCT% did not vary with T2DM. T2DM caused a significant (P =0.01) increase of mean PDW in the cases(13.6 ±4.5fl) compared with the control(11.6 ±2.3fl). The diabetics recorded significantly (P =0.005) higher values for P-LCR (12.7±4.2%) than the control(9.8%±3.2%). The duration of DM type 2 did not (P ≤ 0.05) alter any of the studied parameters. Diabetics individuals with poor glycemic control had significantly(P≤0.05) lower PCT value(0.21±0.05%) than good control group (0.28±0.09%) and fair control group(0.26±0.06%). PLT count c/cmm , MPVfl , PDWfl and PLCR% did not vary with the level of glycemic control It is concluded that Type 2 diabetes mellitus altered some of the platelets indices. It is concluded that Type 2 DM altered some of the platelets indices. Further studies with a large sample size using more advanced techniques are recommended.