Iron Level Among Patients With Chronic Renal Failure On Hemodialysis In Khartoum

Abstract

Anemia is a common in patients with chronic renal failure specially in patients requiring hemodialysis. An important factor in successful treatment of anemia by giving erythropoietin stimulating agent combined with supplementary iron. So, iron status must be monitored regularly to ensure maintenance of adequate iron supplements without adverse effect of excess iron. This study aimed to evaluate body iron status in Sudanese patients with end stage chronic renal failure treated with regular hemodialysis, recombinant erythropoietin and iron supplement, and correlate iron profile with age, gender and duration of hemodialysis. Eighty patients were included in this study from two dialysis centers in Khartoum states (Ahmed Gasim and Asbab hospitals) . Data collected using structured interview questionnaire. Hematological parameters were measured using automated haematology analyzer (sysmex). Serum iron, total iron binding capacity (TIBC), and Serum ferritin measured using Bio system 350 semi automated spectrophotometer, and transferrin saturation percentage was calculated using the results of serum iron and total iron binding capacity. Data analyzed using statistical package for social sciences (SPSS). Seventy five out of eighty patients (93.7%) were received regular intravenous iron dextran with EPO, and 5 patients (6.3%) were received oral iron. Sixty five patients out of eighty (81.2%) were found to have anemia with Hb concentration <11 g\dl, the mean was 9.69±1.72. While high S.ferritin level with more than 800 µg\l were found in 71.2% of patients (57\80), of them the TSAT was > 50% in 27 patients (33.8%). Increase S.ferritin was statistically significant with duration of dialysis and with increase intravenous iron doses, result values were 0.017 and 0.040 respectively. There were no influence of patients age or gender on iron profile. In conclusion, patients with HDCKD who were treated with intravenous iron are prone to iron over load.