Comparative Study of Different doses of Ketamine with Xylazine in Monkeys. In Kuku Zoo East Nile Khartoum State

Abstract

This study was conducted to compare between two general anesthetic protocols in monkeys using Ketamine HcL as sole anesthetic agent with Xylazine HcL as premedication drug. Two intramuscular anesthetic protocols were used to anesthetize eight clinically sound green monkeys. The first intramuscular protocol was achieved by using Ketamine at dose rate (2.5mg kg-1 ) and the second anesthetic protocol was obtained by using Ketamine (5mg kg-1 ), both anesthetic protocols were performed in Xylazine (1mg kg-1) premedicated monkeys. Clinical parameters such as Respiratory rates, heart rates, and rectal temperature were monitored; some anesthesia phases (induction time, Duration of anesthesia and recovery time) were recorded. The quality of both induction and recovery with the degree of muscle relaxation and some selected anesthetic reflexes were observed. Both anesthetic protocols were safe, no incidence of apnea was observed, the anesthetic protocol using Ketamine at dose 5mg kg-1 with Xylazine (1mgkg1) showed significant increase in the duration of anesthesia compare with the other protocol. It could be concluded that both intramuscular anesthetic protocol were suitable for many surgical interventions in monkey, however, the protocol using Ketamine in dose rate of 5mg kg-1was found to be superior to the other protocol.