Estimation of Some Liver EnzymesAmong Sudanese Using Atorvastatin Drug

Abstract

Background:The primary uses of atorvastatin are for the treatment of dyslipidemia and the prevention of cardiovascular disease. Decreases in cholesterol levels were dose-related and stability throughout the treatment period. Objective: To estimation of serum AST, ALT,and ALP among Sudanese using Atorvastatin drug. Methodology:Thisstudy was conducted in period between Marchto May 2017, included 80 participants 50 patients(60%) as cases and30 indiveduals(40%)as control with age between (20-70)years. Case group included 60% female and 40% male, used different doses of drug (10, 20 and 40 mg/day) and different durations using for variable conditions such as (DM, HTN or protection for risk of CVD). Control group was matched with cases group in age and gender but not used any lipid lowering drugs. The samples were obtained after filling a proper questionnaire. The estimation of liver enzymes was doneby fully automated Cobas c311analyzer. Results: The results showed insignificant difference in the liver enzymes activity in cases and controlgroup as following: in cases(21.34±7.26) (15.46±12.88) (85.04±20.23)compared to control (26.03±6.52),(18.00±12.88),(81.73±36.91) by P-value(0.044,0.470,0.606 for AST,ALT,and ALP respectively).No correlation between duration of drug used and concentration of AST,ALT, andALP (P-value: 0.213, 0.999, and 0.701 respectively) Conclusion: insignificant difference of AST, ALT andALP activity between cases and control, no correlation between duration of drug use and concentration of AST, ALT and ALP.