Effects of Warfarin Dose on Some Haemostatic Parameters in some Patients Referred to Sudan Heart Center in Khartoum State 2011

Abstract

This is a cross-sectional descriptive and analytical study, conducted at Sudan Heart Center during the period of February to June 2011. The aim of this study was to assess the haemostatic parameters(Prothrombin time(PT), International normalized ratio(INR) and Activated partial thromboplastine time (A PTT) ) in Oral anti coagulated (warfare )people who attended Heart Center, One hundred warfarin administrated patients as study group, and twenty five (25) of healthy warfarin administrated non (control), The participants were informed about the study and agreed for participation. The study population was divided into four groups according to type of disease: RV +Repair, DVT, PE, AF. 1.8 ml of venous blood drained into 0.2 tri-sodium citrate container from each subject, these were tested for PT, INR and APTT level. Fully automated hematological analyzer (sysmex CA500) was used for analyzed PT, INR, APTT, and Statistical analysis showed significant increase in PT mean (13.09sec), INR mean (1.11), and PTT mean (31.38sec) in non warfarin administrated administrate patient PT(35.90sec), in comparesion with warfarin INR (2.95), PTT (35.13sec)were P.value (0.000) (0.005) (0.000) respectively. There insignificant (P.value 0.43) was noted between the Age group (cases) in PT (sec) mean, and also was insignificant in PTT (sec) mean P.value (0.29) and insignificant in INR mean P. value (0.68). The study was also showed that there was insignificant in warfarin dose (mg) group in PT (sec) P.value (0.51), in INR P.value (0.58) and in PTT (sec) P .value (0.34).The result was significant in INR range compared with administrated warfarin were in control INR value (1.0) and in cases (2.37) p. value (0.000) and there was also significant between INR Range in cases(warfarin administrate ) and control (non warfarin administrate ) were ( 2—3) , (1—2 )respectively , P .value ( 0.000).