Estimation of Creatine Kinase with Thyroid Hormones in Sudanese Patients with Thyroid Dysfunction

Abstract

This study was conducted in Khartoum state in Military Hospital to compare creatine kinase (CK) level and thyroid hormones in thyroid dysfunction patients with healthy individuals.To do this hundred adult Sudanese individuals aged (25male:75female), (19 as – 76 study years) group were (50 participate with in the hyperthyroidism study : 50 hypothyroidism) in addition to fifty with normal thyroid function as control group . At P < 0.05 estimated Creatinine Kinase was significantly decrease in patients with hyperthyroidism and significantly increase in patients with hypothyroidism compared with the control group (P-value 0.000).The results were formed to be as follow: (18±6 U/L) versus (109±38U/L) for hyperthyroidism and (335±119U/L) versus (109±38U/L) for hypothyroidism.Significant correlation found between total CK, age and sex in hyperthyroidism and hypothyroidism P-value (0.04, 0.05), (0.04, 0.03) respectively.Also there was Significant correlation detected between total CK and TSH in hyperthyroidism and hypothyroidism with p-value (0.05) and (0.003) respectively. Significant correlation between total CK and T4 & T3 in hyperthyroidism with p-value less than 0.05 ,p-value is (0.04) for both ,also there was significant ‫‪p-value‬‬ ‫‪with‬‬ ‫‪hypothyroidism‬‬ ‫‪in‬‬ ‫3‪T4&T‬‬ ‫‪and‬‬ ‫‪CK‬‬ ‫‪between‬‬ ‫‪correlation‬‬‫‪(0.04&0.03) respectively. This study demonstrated that hyperthyroidism‬‬ ‫‪decrease total serum CK level ,in contrast hypothyroidism can elevate total‬‬ ‫‪serum CK level .Also the study found that there was positive correlation in‬‬ ‫‪creatine kinase and thyroid stimulating hormone (TSH) and negative‬‬ ‫‪correlation with thyroxine (T4) and tri-iodothyronine (T3). CK level must be‬‬ ‫.‪assessed and screened for patients with thyroid dysfunctions‬‬