Estimation of serum Levels of High Sensitive C - reactive Protein and Lipid Profile among Sudanese Smokers

Abstract

A case control study conducted during the period from March 2013 to July 2013, to evaluate the serum levels of hsCRP and lipid profile in 60 Sudanese smokers from Khartoum state as test group and 40 health non smokers as control group. Age and sex of test group matched with control group. Spectrophotometer and reagent from Bio System Company used to estimate levels of lipid profile, and the hsCRP levels measured by using fluorescence immune assay technology (sandwich immune detection method). Statistical package of social science (SPSS version 11.5) computer software, independent sample t test and correlation used for data analysis. The mean of serum levels of total cholesterol, LDLc and hsCRP were significantly increase in smokers when compared with non smokers (P-value 0.000) The mean of serum level of triglyceride in smokers was not significantly differing from non smokers (P.value 1.371). The mean of serum levels of HDLc was significantly decreased in smokers when compared with non smokers (P-value 0.000). In the smokers group there is significant positive correlation between serum levels of total cholesterol, LDLc and serum levels of hsCRP; and no significant correlation between HDLc and hsCRP. Also in smokers group there is significant positive correlation between serum levels of hsCRP, total cholesterol, LDLc and duration of smoking. From the result of this study, it is concluded that: smoking increases the serum levels of hsCRP, total cholesterol, and LDLc, decrease the serum levels of HDLc and hence the risk of cardiovascular disease increase in smokers' more than non smokers; and it is not affect the serum levels of serum levels of triglyceride.