Evaluation of some coagulation tests among Sudanese Hypertensive patients in Khartoum State

Abstract

This is descriptive analytical study carried out in Khartoum state in Turkish hospital, and laboratory administration, in the period from (March 2011 to August 2011) to evaluate some coagulation tests among Sudanese Hypertensive patients in Khartoum State. Hundred diagnosed hypertensive patients were selected 42(42%) male and 58(58%) female and fifty healthy individuals were selected as control group. 4.5ml of venous blood was with drown from each patient, placed in tri sodium citrate container, then centrifuge to get platelets poor plasma (ppp) and that is to assess PT, APTT, fibrinogen and D-dimer. The results were analyzed by use SPSS version11.5, and express as means. The results obtained from patients that the means of PT( Prothrombin time), APTT (Activated partial thromboplastin time), fibrinogen and D-dimer in patients group. The mean of PT, APTT, fibrinogen and D-dimer in control group, (13 sec), (30.6 sec), (221 mg/dL) and (0.14 mg/L) respectively. The results showed no significant differences between the mean of patients and controls in the Prothrombin time (PT) (p value >0.005) and Activated Partial Thromboplastin Time (APTT) in both sex (p value >0.005) while results demonstrated a significant differences between the mean of patients and controls in Fibrinogen level and D-dimer in both sex (p value <0.005). The results obtained indicated that measurement of Prothrombin time (PT) and Activated partial thromboplastin (APTT) were unnecessary when evaluating hypertensive patients whom there was clinical evidence of hemostatic abnormality. The results of this study raised the possibility of that fibrinogen level and D-dimer could be use in identifying risk group of hypertensive patients who were likely to develop thrombotic events.