Synthesis of some dihydropyrimidinone derivatives

Abstract

In the present work, some new functionalized dihydropyrimidinones were prepared, this include a three component cyclocondensation reaction of benzoylacetone, an aldehyde and urea, in the presence of catalytic amount of Zinc chloride in ethanol. The yield percentage is (35, 47, 49, 84 %). The reaction progress was followed by TLC. The reaction products were recrystallized from appropriate solvents and pure samples were subjected for m. p, IR, UV and mass spectroscopic analysis. Possible mechanistic explanation of the synthetic routes together with retro synthetic analysis discussed