Plasma levels of ALT, AST and ALP among Sudanese Patients with Pulmonary Tuberculosis in Khartoum State

Abstract

This study was conducted to measure plasma levels of s( AST, ALT, ALP) liver enzyme in patients with b tuberculosis in Khartoum state . Fifty samples were collected from patients during the period between April to May 2017 , from randomly chosen patients diagnosed with pulmonary tuberculosis un der taking the treatment for 2 months from Alshaab teaching hospital and fifty apparently healthy individuals serve as control group. Cobas integra 400 plus was used to estimate plasma levels of ( AST, computer program . The study results showed that , plasma levels of AST , ALP were significantly increased in patients group compared to control group (mean ± SD for cases versus control for (AST,ALP) : (32.04 ± 18.15 IU\L ,p-value =0.00) (141.02 ± 145.20 IU\L , p-value =0.00) respectively . The results of this study showed that , there were significantly increased in the levels of plasma AST , ALT , ALP in male patients compared to female (mean ± SD) for male versus female (43.28 ± 19.47 versus 20.80 ± 5.51 IU\L p-value =0.00) , (28.80 ± 21.55 versus 15.61 ± 9.10 IU\L p-value =0.01) and (181.08 ± 194.30 versus 99.96 ± 42.19 IU\L p-value =0.05) respectively . The results of this study showed that , there was significant decrease in the mean of BMI in patients with pulmonary tuberculosis compared to control group (mean ± SD for case versus control (0.17 ± 18.68 ) versus (21.54 ± 1.72 ), p-value = 0.04) . common among age between (19-49) years 70% and 30% of patients between age (50-82) years , this disease most abundant in male (60%) than female (40%) . Person correlation showed no correlation between plasma levels of AST , ALP and age (r = 0.15, p-value =0.30) (r = 0.18 , p-value = 0.77) respectively .

Person correlation showed a significant weak negative correlation between plasma level of ALT and age (r = -0.18 , p-value = 0.05). In conclusion : the plasma levels of AST , ALP were significantly increased and there was insignificant difference in ALT in patients with pulmonary tuberculosis under taking the treatment for 2 months in Khartoum state .